Precision BioSciences announces new and late-breaking PBGENE-HBV clinical data from the ELIMINATE-B study at european association for the Study of the Liver Congress 2026
[출처/시간] Briefing.com - 6:01 AM ET, 05/27/2026 New biopsy data demonstrate that PBGENE-HBV directly eliminated cccDNA through its primary mechanism leading to a 1-log (10-fold) reduction in cccDNA-derived transcripts.In the <1% of cccDNA remaining, PBGENE-HBV indels permanently inactivated viral replication by knocking out polymerase function.gRNA established as the biomarker to directly reflect cccDNA elimination by PBGENE-HBV -New clinical data
[출처/시간] Briefing.com - 6:01 AM ET, 05/27/2026
New biopsy data demonstrate that PBGENE-HBV directly eliminated cccDNA through its primary mechanism leading to a 1-log (10-fold) reduction in cccDNA-derived transcripts.In the <1% of cccDNA remaining, PBGENE-HBV indels permanently inactivated viral replication by knocking out polymerase function.gRNA established as the biomarker to directly reflect cccDNA elimination by PBGENE-HBV -New clinical data demonstrate that PGENE-HBV achieved pgRNA loss in 100% of patients with detectable pgRNA at baseline -PBGENE-HBV has a clear therapeutic window with a well-characterized and manageable safety profile across multiple dosing cohorts -
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